This is another early Grand Slam exit from Tsitsipas, who lost to Novak Djokovic in the 2021 final.
The 26-year-old has now failed to surpass the second round of the past four majors, which was his first defeat at Roland Garros since 2018.
The failure means that Tsitsipas will outperform the world’s top 20 for the first time since August 2018.
By claiming his biggest win in his career, Gigante made his debut at the French Open after the qualifying round – with the 3rd round meeting with the 13th seed of the United States Ben Shelton.
Elsewhere, American duo Tommy Paul and Frances Tiafoe entered the last 32 games under different circumstances.
Paul was the twelfth seed, making an impressive comeback after two defeats of Hungary’s Marton Fucsovics 4-6 2-6 2-6 6-3 7-5 6-4.
Paul will face Russia’s No. 24 seed Karen Khachanov, who beat Austria’s Sebastian honor 7-5 3-6 7-5 4-6 6-2 to win 7-5 3-6 7-5 4-6 6-2.
The 15th seed Tiafoe is the 6-4 6-3 6-1 champion of Pablo Carreno Busta in Spain.
At the meeting of Philippe Chatrier in court at night, the 10th seed of Denmark Holger runes parade US World No. 138 Emilio Nada 6-3 7-6 (7-5) 6-3.
Meanwhile, Italy’s eighth seed Lorenzo Musetti entered the third round with a 6-4 6-0 6-4 victory.
In the men’s doubles match, Jacob Fearnley, who won his first French open singles match on Monday, entered the second round safely with Canada’s Gabriel Diallo, defeating Nicolas Barrientos and Nicolas Barrientos of Colombia and India 6-0 6-2, respectively.
Briton Luke Johnson entered the second round of the Grand Slam for the third time as he and his Dutch partner Sander Arends defeated Marcelo Demoliner and Nicolas Jarrine 3-6 6-3 7-6 (10-6).
